The Role Of  Polycystic Ovary Syndrome In Reproductive Health And Metabolic Disorders: Original Article

Sara Gul; Amira Babi; Shadab Mumtaz; Sidra Gohar; Gul-E-Lala Khalil

doi:10.69837/pjammr.v3i1.60

Authors

Sara Gul
Amira Babi https://orcid.org/0000-0002-5887-6860
Shadab Mumtaz
Sidra Gohar
Gul-E-Lala Khalil

DOI:

https://doi.org/10.69837/pjammr.v3i1.60

Keywords:

reproductive disorders, metabolic syndrome, insulin resistance and PCOS

Abstract

Background: Polycystic ovary syndrome (PCOS) is an endocrinopathy that affects between 6-10% of women of childbearing age across the world. It affects the reproductive system, influencing fertility and the menstrual patterns, and increases susceptibility tent to metabolic diseases, including obesity, insulin resistance, and type II diabetes; therefore, its early identification is important.

Objectives: to analyse the relationship between PCOS, reproductive disorders, and metabolic abnormalities in women and to determine biomarkers as well as effective treatment measures that may contribute to the prevention of future health issues among these patients.

Study Design: A cross-sectional study.

Duration and Place of Study. Department of Obstetrics & Gynecology Gajju khan medical College Swabi from 05-jan 2024 to 05-june 2024

Methods: 100 women of age range 18-35 years diagnosed to have PCOS conforming with the Rotterdam criteria were used. They also received clinical, hormonal, and metabolic evaluations depending on randomization. Samples were obtained, and information regarding menstrual histories, fertility, BMI, fasting blood glucose, and lipid panel was obtained. Data analysis was done using the Statistical Package for the Social Sciences (SPSS) with alpha set at 0.05.

Results: PCOS patients had a higher BMI mean = 30.5, SD = 5.2 kg/m² compared to non-PCOS patients mean = 25.8, SD 3.6kg/m² F = 38, p = 0.001. Most patients (68%) had insulin resistance (HOMA-IR 4.2 ± 1.3), and 76% of patients had menstrual irregularities. They were further asked about their fertility, and 42% reported they were infertile. Lipid abnormalities (total cholesterol: (220 ± 45 mg/dL) were considered to be present, greatly indicating the relationship between PCOS and metabolic disorder.

Conclusions: PCOS has major implications for reproductive and metabolic health; globally integrative models of care are required. The proper and prompt identification of metabolic precursors and personalization of current and future management plans can enhance the prognosis of affected women with PCOS.