Changes in Blood Vessel Morphology in Erythematous Skin of Atopic Dermatitis Patients

Original Article

Abstract

 Background: Atopic dermatitis is an inflammatory skin disease characterized by erythematous changes and abnormalities in microvasculature. Regarding the research questions, this cross-sectional study conducted from January 5 to July 5, 2019 at Watim Medical and Dental College, Rawat and the findings on observed vascular alterations supposed to present the mean age, standard deviation and p-value as follows:

Objectives: , the morphology of the blood vessels in the erythematous skin of the patients with AD and controls matched based on their age will be examined.

 Study Design: A Cross-sectional study.

 Place and Duration of Study: from 05-Jan-2019 to 05-Jan-2020 in the Department Pathology, Watim Medical and Dental College Rawat, Pakistan.

Methods: This descriptive cross sectional study recruited the patients from the Department of Pathology, Watim Medical and Dental College, Rawat over a period of six months from January 5, 2019 to July 5, 2019. Adult patients, comprising 100 in number, diagnosed to have atopic dermatitis were used in the study. The patient ages were noted down and dermoscopy of the morphological changes occurring in the blood vessels at erythematous lesions were observed. Descriptive statistics were used in a bid to calculate mean age, standard deviation as well as the p-value. This research study was reviewed and cleared by the Institution’s ethical committee before its conduct.

Results: Patients 100 Patients were selected for the study, Moreover the patients diagnosed with atopic dermatitis were between the age group of 18-65 years with mean age of 35. 4 years (SD 12. 7), refer to the table 1. Morphological assessment of blood vessels in erythematous skin showed that 60% of the patients were having abnormal morphological pattern whereas 40% of patients demonstrated normal morphology (table 2). Co-relating and comparing the normal and altered Vascular architecture mathematical statistics revealed the fact with P-values equal to 0. 045 (Table 4). The findings of increased vascular alterations in lesions of atopic dermatitis evident from the results in Table 5 indicate that blood vessel alterations are associated with the severity of skin condition rashes.

 Conclusion: our study identify that extensive vascular changes at the skin of those with atopic dermatitis while stressing on the importance of these changes in disease progression. Targeted therapies for the aforementioned vascular changes could be promising in the future as compared to the ones that address mere clinical manifestations.

 Keywords: AMD, Vasculature, Redness of the Skin, Swelling.